Infective Endocarditis (IE) Prophylaxis
Indications (AHA 2007)
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Prosthetic valve
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Previous IE
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Congenital heart disease, specifically:
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Unrepaired cyanotic heart disease, including palliative shunts & conduits
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Congenital heart disease repaired within the last 6 months
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Repaired but residual defects next to prosthetic material
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Heart transplant recipients with valvulopathy
Eligible Operative Procedures
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Dental procedures with mucosal penetration
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Procedures involving respiratory tract incision (including bronchial biopsy)
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Procedures involving infected skin/musculoskeletal tissue
Antibiotic regimens
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One dose 30-60 min prior to the procedure
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Recommended agent is amoxicillin
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2g PO for adults
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50mg/kg PO for children
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Keflex
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2g PO for adults
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50mg/kg PO for children
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Ampicillin
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2g IV for adults
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50mg/kg IV for children
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Cefazolin or ceftriaxone
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1g IV for adults
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50mg/kg IV for children
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Clindamycin
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600mg IV for adults
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20mg/kg IV for children
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Azithromycin or clarithromycin
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500mg PO for adults
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15mg/kg PO for children
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